The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase — Mark L. Cunningham

The capability to accurately, rapidly, and reproducibly determine the affinity of a ligand for a target protein or enzyme is a vital component for a successful structure-based drug design effort.

Tür:: Kitap Bölümü
Yazar:: Mark L. Cunningham
Yayın yılı:: 2011
Yayıncı:: Humana Press
Dil:: en

The capability to accurately, rapidly, and reproducibly determine the affinity of a ligand for a target protein or enzyme is a vital component for a successful structure-based drug design effort. In order to successfully drive a structure-based drug design (SBDD) project forward, multiple distinct assays, each with particular strengths and weaknesses, need to be employed. Using bacterial DNA gyrase as an example, a range of assays are described that will fully support an SBDD program.

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The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase ne hakkında?: The capability to accurately, rapidly, and reproducibly determine the affinity of a ligand for a target protein or enzyme is a vital component for a successful structure-based drug design effort.
The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase kim tarafından yazıldı?: Mark L. Cunningham